
CD4 ICE-T

The Target
- CD4 surface receptor expressed on T cells
- Marker for T helper cells
CD4 ICE-T
- Visualization of the presence and migration of CD4+ T cells
- Therapy-monitoring of CD4+ T cells affecting therapies
Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4+ Cells, Traenkle B et al., Frontiers in Immunology, 2021, doi.org/10.3389/fimmu.2021.799910
SIRPα ICE-T

The Target
- SIRPα surface receptor expressed on myeloid cells
- SIRPα/CD47 known as ‚don’t eat me signal‘
SIRPα ICE-T
- Visualization of the presence and recruitment of myeloid cells
- Therapy-monitoring of myeloid affecting therapies
Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells, Wagner TR et al., Frontiers in Immunology, 2023, doi.org/10.3389/fimmu.2023.1264179