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Pipeline-Backup

CD4 ICE-T
50%
SIRPα ICE-T
40%
ICE-T 3
30%
ICE-T 4
20%
CD4 ICE-T

The Target

  • CD4 surface receptor expressed on T cells
  • Marker for T helper cells

CD4 ICE-T

  • Visualization of the presence and migration of CD4+ T cells
  • Therapy-monitoring of CD4+ T cells affecting therapies

Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4+ Cells, Traenkle B et al., Frontiers in Immunology, 2021, doi.org/10.3389/fimmu.2021.799910

SIRPα ICE-T

The Target

  • SIRPα surface receptor expressed on myeloid cells
  • SIRPα/CD47 known as ‚don’t eat me signal‘

SIRPα ICE-T

  • Visualization of the presence and recruitment of myeloid cells
  • Therapy-monitoring of myeloid affecting therapies

Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells, Wagner TR et al., Frontiers in Immunology, 2023, doi.org/10.3389/fimmu.2023.1264179